He mea nui loa nā'elīpuma i ka hoʻopaʻaʻana i nā hana e hanaʻia ana ma ka mahele o ka membrane paʻakikī me nā hana hoʻohui. Hiki ke hana i kēia mau mea i loko o nā ana o ke kinano, kahi e wehe ai kekahi mau kinipona pūmua i ke ala no nā ioni calcium.
Kahi a me ka hana o nā kelemona
Hoʻokomoʻia kēia mau pūnaewele iʻekoluʻano:
- Cytoplasmic;
- Sakrolemalnye;
- kūpū.
ʻO ka hapa nui o nā kahawai calcium aia i loko o ka'ōpū o ka naʻau, aʻo nā mea i koe i loko o nāʻiʻo muscle o ka maʻi, ke kōpū, ka pūnana o ka lolo, kaʻaila a me nā platelets.
E like me ka mea i haʻi muaʻia, nā kinona calcium e hoʻopili i nā hana hana kūmole i loko o ke kino,
- ka piʻiʻana i ka oxygen koi.
- ka puʻupuʻu hoʻoikaika hana;
- ka piʻi nui.
No ka hoʻopauʻana i kēia hana ma nā lāʻau lapaʻau,ʻo nā lāʻau lapaʻau e pili ana i ka hui o nā kalaiwa o ke kahawai calcium (BCC) a iʻole hoʻi i kapaʻia lākou he mau kelepona kelepona.
Nā hōʻike no ke hoʻohana a me ka hopena maikaʻi o ka BPC
Hoʻopaʻaʻia nā hana lapaʻau o nā kelepa o ke alaponi konupora i mua o nā maʻi ma muli iho nei:
- ka piʻiʻana;
- angina pectoris ;
- ka lawaʻole o ke koiʻana;
- Ka hui pūʻana o angina me bradycardia;
- tachycardia;
- puʻuwai hauʻoli;
- nā pilikia o ke kaʻina o kaʻoki;
- ka hoʻokahuliʻana i ka puʻuwai o ke aniolo axquined;
- Ka maʻi o Raynaud .
Hoʻopiliʻia, hiki ke hoʻoponoponoʻia ka BPC no nā maʻi o nā pūpū kino, nā meaʻaeʻa, bronchospasm a me kekahi mau maʻiʻehaʻeha (ka maʻi Alzheimer, ka dementia senile, ka waiʻona).
ʻO keʻano o ka hanaʻana o nā mea hoʻohemo o ke kahawai kūmole i ke kino, he kumu ia:
- ua emi iho ka leo o ka moale;
- ka maikaʻi o ke kahe o ka wai;
- ua hoʻohaʻahaʻa i ka naʻau;
- hana hoʻololi;
- ka emi o ka wikiwiki o nā pulina;
- he emi ma ka papa o ka hōʻuluʻulu pālahalaha a me ka hoʻonuiʻana i ke koko.
Ka hoʻolahaʻana i nā hua lāʻau
Hiki ke hoʻohālikeʻia ka heluna a me ka'āpana'āina i loko o:
- Nā hopena o ka dihydropyridine. Hoʻokumuʻia kēia mau lāʻau lapaʻau ma ka nifepidine. He mau mea koʻikoʻi ko lākou i nā moku o ka lolo (Corinfar, Ardalat, Cordaflex, Lomir, Plendil, a pēlā aku).
- Nā huahana Phenylalkylamine. ʻO ka huiʻana o nā kamaliʻi. ʻO ka hopena o ka puʻuwai ka puʻuwai, e hoʻohaʻahaʻa ai i kona kuʻikahi. Ua nāwaliwali ka hopena o nā moku (Isoptin, Prokorum, Finoptin).
- Nā huahana Benzothiazinine. ʻO ka hui diltiazem. ʻO ka hopena o kēia mau lāʻau lapaʻau he lalo ia ma mua o ka hui mua, akā, ua māhele likeʻia i ka naʻau a me nā moku (Dilsem, Cardil).
- Nā huahana o diphenylpyrazine. ʻO ka hui o cinnarizine. ʻO ka mea pinepine, ua kauʻia kēia mau CCB no nāʻepa o nā moku lolo (Stugeron, Nomigrain).
Eia kekahi, ua māheleʻia nā'āpana o ke kelepona calcium i ka mua a me ka lua o nā hanauna, aʻo ka hapalāʻau o ka dihydropyridine kahiʻekolu. ʻO ke kumu nui ma waena o nā hanauna,ʻo ia ka hoʻomaikaʻi houʻana i nā mea kanu lāʻau a me ka emiʻana o nā hopena maikaʻiʻole ma hope o ka laweʻana i ka lāʻau lapaʻau. Eia kekahi, ke kau nei nā lālaniʻelua a me ke kolu i nā lā o kēlā me kēia lā, a he mea pono ke hoʻohanaʻia i nā manawa he 1-2 wale nō i ka lā. Aia nā'āpana o nā kahawai calcium o ke kolu o ka hanauna e like me'Amlodipine, Latsidipin, Nimodipine.
Hoʻohana a me nā hōʻai'ē
ʻAʻole hiki keʻaeʻia ka BPC ma hope o ke kūkākūkā kūkāʻana me ka
ʻO kēlā me kēia lāʻau lapaʻau i kāna mau hōʻailona hōʻoia, akā i ka mea maʻamau,ʻaʻole lākou e'ōleloʻia no ka hoʻohanaʻana inā:
- ka hōʻeha kino;
- ka hōʻeha hauhaʻi;
- ka'ōpū, i ka manawa o ka hānaiʻana;
- 'ōpiopio;
- kēlā me kēia ponoʻole;
- maʻi maʻi a me nā pilikia ma nā puʻupaʻa a me ke ake.