17-OH-progesterone (17-hydroxyprogesterone, 17-OGG, 17-oh-progesterone) keʻano o hormones; i keʻano o ka "hua i hoʻopihaʻoleʻia", mai ia mau mea e hanaʻia ai nā hormones (cortisol, estradiol, testosterone) i loko o ka māhele koʻikoʻi o nā hoʻololi hana.
ʻO nā kumu o ka hoʻonuiʻana i ka 17-OH-progesterone
ʻO ke kumu no ka piʻiʻana o ka 17-oh-progesterone i ka loaʻaʻana i nā'aleʻa a me nā ovaries. ʻO ka maʻi hoʻopiʻi kūikawā (PDCN) ka hopena maʻamau o kēia ulu. Hoʻopiliʻia ka'ākau o Adrenal i kahi hemahema a nele paha i kahi 21-hydroxylase enzyme, a, me 17-OH-progesterone, ke komo i loko o ka synthesis o ka hormone cortisol. Ke kali nei ka enzyme ma nā'āpana liʻiliʻi, i kēia manawa ke hanaʻia nei ka mua o nā hormones 17-OH-progesterone i ka hopena o ka maʻamau.
ʻEluaʻano likeʻole o VDKN: kūlana kūikawā a me ka papa inoaʻole. Ua hoʻokumuʻia ka papahana VDKN kahiko i nā lā / mahina mua o ke ola o ke keiki ma nā hōʻailona o waho o kānamaphroditism wahaheʻe. No ka hōʻoiaʻana i keʻano nonclassical o VDKN, ma keʻano he kūlana, hiki i ka'ōpiopio wale nō (ma hope: hirsutism,ʻene,ʻene,'ākauʻole o ka menstrual) a iʻole i ka makahiki hānau (ke hoʻopilikia nā wāhine i ka pilikia o ka hānauʻana a me ka hanaʻana).
Eia kekahi,ʻo ka ho'āʻoʻana i ke koko no ka hoʻoholoʻana i ke kiʻekiʻe o ka 17-OH-progeterone hiki ke hōʻike i kaʻoi aku o ke kūlana maʻamau inā:
- ka maʻiʻeleʻele polycystic (PCOS);
- androgen-producing tumors of the ovaries or gorgeous glands;
- maʻi a maʻi paha o Itenko-Cushing;
- maʻi maʻi hypothalamic;
- ka hyperprolactinemia ;
- a me nā maʻi'ē aʻe.
ʻO nā koina maʻamau o 17-OH-progeterone
ʻO nā mea maʻamau o nā hormones o ka wahine, e like me ko lākou mua 17-OH-progesterone, hiki keʻano likeʻole i nā hale wehewehe hoʻokolohua likeʻole. I loko o ka hōʻailona e pono ke alakaʻiʻia e nā kuhikuhi kuhikuhi o kahi laboratory, i ka manawa i hōʻikeʻia i nā hualoaʻa o ka hoʻoponopono.
Manaʻo nā lunaʻepekema i ke kiʻekiʻe o ka 17-OH-kelepaʻi i loko o kahi wahine olakino olakinoʻole e koi aku i ka mālamaʻana a heʻano likeʻole ia. ʻO ka palena o kēia hoʻonui he 5 nmol / L = 150 ng / dl = 1.5 ng / l.
ʻAʻole hiki i nā wāhine hānai ke hoʻokolo i ke koko no ka 17-OH-progesterone, i ka wā o ka hāpaiʻana, ke piʻiʻia ka kiʻekiʻe o 17-GPG,ʻo kēiaʻano heʻanoʻoihana physiological. Aʻo kaʻoi aku ka maikaʻiʻole o ka kauʻana i ke kaukani ma kahi kiʻekiʻe kiʻekiʻe o 17-OH-progesterone i ka wā o ka hāpaiʻana. ʻO nā kumu wale nō ke kumu o ka VDKN maʻamau.
Pehea e hoʻemi ai i ka 17-OH-progeterone?
Inā, e like me nā hopena o nā hoʻokolohua, ua hoʻonuiʻia ke kiʻekiʻe o ka 17-OH-progesterone, he mea nui e hoʻomaopopo i nā kumu o ka hana hewa ma mua o ka hoʻomakaʻana i ka hana. ʻO nā makapō "makapō", e hanaʻia e nā kauka, e hilinai ana i nā kūlana o ka lāʻau hoʻoholo,ʻaʻole i kōkua i ka pilikia, akā pinepine pinepine ia.
No laila, pehea e ho'ēmi ai i ke kiʻekiʻe o 17-OH-progesterone? Ma waho o ka mea i hoʻoulu i ka uluʻana, ua kauohaʻia kekahi wahine e hoʻohana i nā hana kuʻuna waha o COC i ka manawa lōʻihi (Jess, Yarin, Diana-3, a me nā mea'ē aʻe). No laila, ināʻikeʻia kekahi wahine i ka PCOS, me ka hana maʻamau o nā kēpau o ka COC-therapy ma mua o ka'ōpūʻana, ua lawa ia.
Ināʻo ka kumu o kahi kiʻekiʻe he 17-'OCG he VDKN nonlasslassical, pono e nānā pono i ka endocrinologist a me nā genetics pono,
ʻO ka lōʻihi o ka 17-OH-kūkākūkā i ka hapanui o nā hihia he pilikia kūponoʻole ia. ʻO ka Dexamethasone, prednisolone a iʻole nā kānaka'ē aʻe e pono ke laweʻia wale nō ma ka hihia o ka PDCA nonclassical i hōʻikeʻia a hāʻawi waleʻia no ka hikiʻole i ka'ōpū ke piʻi ma mua o hoʻokahi makahiki, aʻo nā kumu kumu'ē aʻe a pau o ka hemoʻole.